However, how descending pathways from cortex interact subcortically as a network largely remains unknown. Each cortical area sends descending projections that innervate subcortical structures through hierarchically organized, serially-ordered, multi-synaptic neural pathways. Current advancements in microscopy and computational technologies have made it feasible to produce, collect, and analyze vast amounts of connectivity data to assemble neural networks of the neocortex in mice 1, 2 and rats 3, which inform research about primate cortical networks 4. Given its role in higher order functions like cognition and emotion, the cerebral cortex has been a main focus of neuroscience in the last century. Together, this work provides the structural basis for studying the functional diversity of the dorsal striatum and disruptions of cortico-basal ganglia networks across a broad range of disorders. The workflow was also applied to select cortico-striatal connections in two different mouse models of disconnection syndromes to demonstrate its utility in characterizing circuitry-specific connectopathies. Further, we characterize different cortico-striatal networks and how they reconfigure across the rostral-caudal extent of the CP. Based on these projections, we use novel computational neuroanatomical tools to identify 29 distinct functional striatal domains. Here, we report an open-access comprehensive mesoscale cortico-striatal projectome-a detailed connectivity projection map from the entire cerebral cortex to the dorsal striatum or caudoputamen (CP) in rodents.
How descending pathways from the entire cortex interact subcortically as a network remains unclear. Different cortical areas are organized into distinct intra-cortical subnetworks.
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